There are five Pastoral Regions in the Archdiocese of Los Angeles.  They were established in 1986.​

Our Lady of the Angels

• Area: Downtown and central Los Angeles west to Malibu, south to LAX.
• Regional Bishop: Bishop Edward W. Clark
• Parishes: 78
• High Schools: 11
• Hospitals: 5
• Missions: 5

San Fernando

• Area: San Fernando, Santa Clarita and Antelope Valleys.
• Regional Bishop: Bishop Gerald E. Wilkerson
• Parishes: 54
• High Schools: 12
• Hospitals: 2
• Missions: 5

San Gabriel

• Area: East Los Angeles through San Gabriel and Pomona Valleys
• Episcopal Vicar: Msgr. James Loughnane, P.A.
• Parishes: 66
• High Schools: 13
• Hospitals: 3
• Missions: 2

San Pedro

• Area: Long Beach and Southern Los Angeles County
• Regional Bishop: Bishop Oscar Solis
• Parishes: 67
• High Schools: 9
• Hospitals: 6
• Missions: 1

Santa Barbara

• Area: Santa Barbara and Ventura Counties
• Regional Bishop: Bishop Thomas J. Curry
• Parishes: 37
• High Schools: 6
• Hospitals: 4
• Missions: 5